RobustcfDNAandCTCcollectionforliquidbiopsyandNIPT
- Maximizerecoveryof cfDNA,cells&plasmavolume
- NogDNAcontaminationordetectable DNAdamage
- HighestDNAmethylationMarkerintegrity
- Unprecedentedprotectionagainstshippingextremes
Product
LBgardBloodTubesaredirect-drawbloodcollectiontubespre-filledwithaproprietary,reagentthatstABIlizescellsandcell-freeDNA(cfDNA)inwholeblood,preservingBIOLOGicalanalytesfordownstreamapplications.LBgardBloodTubesalsopreventthereleaseofcellularcomponentsthatcaninterferewithanalysis,suchascellulargenomicDNAandproductsfromhemolysis. SamplescollectedinLBgardBloodTubes,whenstoredat4°C–37°C,arestabilizedfordownstreamcirculatingtumorDNAandcell-freeDNAapplicationsforupto14days.
| Properties | LBgard | CompetitorS | CompetitorP |
|---|---|---|---|
| PlasmaVolumeRecovery | |||
| ShippingRobustness | |||
| cfDNAPreservation | |||
| NogDNAcontamination | |||
| PBMC/CTCPreservation | |||
| CellSurfaceProteins | |||
| ProtocolLength | Short | Long | Shortest |
| EaseofPhlebotomy | Easy | Difficult | Easy |
| SplatterPrevention | Excellent | Poor | Poor |
| RiskofTubeBreakage | Low | High | Low |
| MinimalLot-to-LotVariability | N/D |
EvaluationProtocol:BloodCollectionDevice
Selecttherightcollectiondeviceandpre-analyticvariabilitycanbereduced.Thewrongchoicecancauseinterference,delayproductlaunch,andevennecessitatere-validationofdevelopedtests.
Thisevaluationprotocolwillhelpyoudesignanexperimentthataccountsforreal-worldenvironmentalstressesandassesstheoverallrobustnessofperformance.Akeyerrorinselectingthecorrectdeviceisfailingtoincludeshippingtimeandtemperaturestresses.
DOWNLOADEVALUATIONPROTOCOLHERE
Data
Workflow
Figures
Figure1:PlasmaDNAconcentrationsarestabilizedinLBgardBloodTubevsStreckBCTandEDTAtubesover14days.
Figure2:StageIVcoloncancerpatientcfDNAisstabilizedinLBgardBloodTubesfor15days,andgenomicspillageisprevented,comparedtoStreckBCTs.
Figure3:RarecfDNAKRASG12DcancerallelesarepreservedinLBgardBloodTubesfor14dayscomparedtoStreckBCTsasmeasuredbyddPCR.
Figure4:NIPTcfDNApreservedinTrisomyTestRunonDA8600fromLifeTechnologies.
Figure5:CTCsandWBCsarepreservedinLBgardBloodTubes,withsuperiorrecoveryafterfourdayscomparedtoStreckBCTs.
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Specifications
LBgardBloodTubes,CE
- Pre-fillvolume(preservative)=0.6mL
- Blooddrawvolume=8.5mL
- Pre-fillstoragetemperature=4°C–25°C
- Post-fillstoragetemperatureforcfDNA=14daysat4°C–37°C
- Post-fillstoragetemperatureforCTCsandWBCs=4daysat18°C–30°C
- ForExportOnly.NotforsaleintheU.S.
LBgardBloodTubes
- Pre-fillvolume(preservative)=0.6mL
- Blooddrawvolume=8.5mL
- Pre-fillstoragetemperature=4°C–25°C
- Post-fillstoragetemperatureforcfDNA=14daysat4°C–37°C
- Post-fillstoragetemperatureforCTCsandWBCs=4daysat18°C–30°C
- ForResearchUseOnly.Notforuseindiagnosticprocedures.
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